中国药科大学是一所历史悠久、特色鲜明、学风优良、在药学界享有盛誉的教育部直属、国家“双一流”建设高校（一流学科），是我国首批具有博士、硕士学位授予权的高等学校之一，拥有一流药学、中药学类相关专业和创新平台，具备完备的药学、中药学学科体系。（http://www.cpu.edu.cn）。

China Pharmaceutical University is a prestigious institution with a long history, distinctive features, and excellent academic atmosphere. It is directly affiliated with the Ministry of Education as one of the national Double First-Class universities (first-class discipline). It is among the first batch of higher education institutions in China authorized to grant doctoral and master's degrees. The university offers solid pharmacy and traditional Chinese medicine-related programs, along with various innovation platforms. Additionally, it offers a well-rounded and diverse curriculum that covers both pharmacy and traditional Chinese medicine disciplines. Please visit the official website http://www.cpu.edu.cn for more details.

一、课题组介绍

合作导师何牟欣亚，中国药科大学教授，博士生导师，入选国家高层次人才计划。2014年于新加坡南洋理工大学获得博士学位并从事博士后研究，2022年8月加入中国药科大学中药学院。以第一作者（或者共同第一作者）在JACS, PNAS, ACS  Catalysis，New Phytologist，Organic Letters等国际知名期刊发表多篇研究论文，申请国际和国内发明专利2项。担任Frontiers in Nutrition, Molecules等学术期刊特邀编委。

课题组主要从事稳定多肽药物设计与合成研究。天然稳定多肽是一类尚未充分挖掘的可成药活性分子，具有高稳定性，高生物利用度，是生物药的优秀先导体。然其机理研究和成药性受到天然低表达量的局限，因此对其合成途径的解析和人工合成的技术研发是以天然稳定多肽为基础进行新药研发的关键。

课题组的主要研究方向为：

1)天然多肽合成酶的系统性挖掘、设计改造及药物合成应用

2)稳定活性多肽的化学合成技术研发

3)基于稳定多肽骨架的多肽药物设计、虚拟筛选及活性验证

因课题组发展需要，现公开招聘博士后2名，长期有效。课题组保障待遇并全力支持博士后的科研发展，诚邀海内外英才加入。

The group leader is Professor Xinya Hemu, recipient of China Pharmaceutical University’s High-Level Talent Introduction Program, NCSF Distinguished Overseas Young Talent. She received her Ph.D. from Nanyang Technological University, Singapore, in 2014 and pursued postdoctoral research before joining the School of Traditional Chinese Medicine at China Pharmaceutical University in August 2022. As the first author (or co-first author), she has published numerous research articles in internationally renowned journals such as JACS, PNAS, ACS Catalysis, New Phytologist, and Organic Letters, and has applied for two international and domestic patents. She is also an invited editor for academic journals such as Frontiers in Nutrition and Molecules.

Hemu’s research group primarily focuses on the design and synthesis of stable peptide drugs. Natural stable peptides are a class of underexplored drug-like active molecules with high stability and high bioavailability, making them excellent precursors for biopharmaceuticals. However, their mechanistic research and druggability are limited by their low natural expression levels. Therefore, the analysis of their synthetic pathways and the development of artificial synthesis techniques are critical for new drug development based on natural stable peptides.

The main research areas include:

(1)Systematic study of natural peptide synthetic enzymes on discovery, design, modification, and application on drug synthesis

(2)Development of chemical synthesis technology for stable active peptides

(3)Peptide drug design based on stable peptide scaffolds, virtual screening, and functional validation

Two post-doctoral positions are open for application with no immediate closing date. The research group guarantees compensation, and fully supports the scientific research development of postdoctoral researchers.

二、招聘岗位

岗位1：已经或即将获得生物信息学、计算生物学、结构生物学等相关专业的博士学位并有长远科研事业规划的申请人，优先考虑具有酶学相关研究背景的候选人。

工作内容：

1.蛋白结构/动力学/量子力学计算、功能-结构关系图谱的机器学习模型构建、药物虚拟筛选平台构建等相关科研工作；

2.协助进行项目申请和管理；

3.协助指导研究生的科研工作

岗位2：已经或即将获得生物学或药学等相关专业的博士学位并有长远科研事业规划的申请人，优先考虑具有细胞生物学、实验动物学、电生理学背景的博士。

工作内容：

1.先导药物的体内外活性检测平台搭建，药理分析等相关科研工作；

2.协助进行项目申请和管理；

3.协助指导研究生的科研工作

应聘条件：

（1）以第一作者身份在SCI杂志上发表论文或者已经接收；

（2）具有专业的写作和阅读能力，能够积极追踪所研究方向的前沿论文，可独立完成SCI论文的写作；

（3）具备良好沟通和执行能力，可在指导下独立开展课题研究和项目管理；

（4）热爱科研、积极乐观、有很强的责任心和团队合作意识，有坚定的学术追求。 

Position #1: PhD students who are nearing the completion of or have recently completed their studies in Bioinformatics / Computational biology / Structural Biology and are considering a postdoctoral position as the next stage in their career development. Priority will be given to candidates with a research background in enzymology.

Responsibilities:

1.Research work related to protein structure, MD, QM/MM, machine learning model construction for structure-function relationship atlas, development of virtual screening platform;

2.Assist in grant application and management;

3.Guide graduate students in their research work.

Position #2: PhD students who are nearing the completion of or have recently completed their studies in Biology / Pharmacology and are considering a postdoctoral position as the next stage in their career development. Priority will be given to candidates with a research background in cell biology, experimental animal science, and electrophysiology.

Responsibilities:

1.Research works related to the establishment of in vitro and in vivo activity testing platforms for lead drugs, as well as pharmacological analysis;

2.Assist in grant application and management;

3.Guide graduate students in their research work.

Requirements:

1.Have published articles(or with the acceptance letter) as the first author in peer-reviewed SCI journals;

2.Professional writing and reading skills, able to actively track recent research papers in the field, and independently complete SCI article writing;

3.Strong communication and execution skills, capable of conducting research independently and managing project under guidance;

4.Passionate about scientific research, positive and optimistic, with a strong sense of responsibility and team collaboration, with a determined pursuit of academic excellence.

三、岗位待遇

1、根据个人情况，聘为兴药科研博士后（年薪约29万）。同时博士后人员在站期间，享受公费医疗、公积金以及校工会有关待遇。在教学和科研方面取得突出成果，可享受学校相应的奖励政策。出站后，可申报具有正式编制的讲师或副研究员。具体要求及待遇详情请参见《中国药科大学博士后工作管理办法（试行）》https://rsc.cpu.edu.cn/67/83/c4819a157571/page.htm。

2、课题组协助申报国家、省部级课题及相关机构提供的博士后资助（如江苏省卓越博士后计划（15万/年）等）。 

Benefits

The shortlisted candidate will be appointed as a postdoctoral researcher in pharmaceutical sciences with an annual salary of approximately 280,000 RMB. During the postdoctoral period, the researcher will enjoy employee benefits (public medical insurance, housing provident fund, and benefits related to the university labor union). Those who achieve outstanding results in teaching and research can enjoy the corresponding reward policies of the university. After completing the postdoctoral position, candidates can apply for a formal lecturer or associate researcher position. For specific requirements and compensation details, please refer to “China Pharmaceutical University Postdoctoral Work Management Measures (Trial Implementation)” https://rsc.cpu.edu.cn/67/83/c4819a157571/page.htm.

The research group will assist in applying for national, provincial, and ministerial-level projects, as well as postdoctoral funding provided by relevant organizations (e.g. Outstanding Postdoctoral Program of Jiangsu province (150,000 RMB/year) ).

四、申请材料 Documents for application

·个人简历及相关支持材料Resume and supporting documents

·代表性科研成果Representative Research Achievements

·求职信（简述科研兴趣和发展规划）Cover letter (Briefly introduce your research interests and future plan)

·3 封推荐信（由推荐人直接发送至联系人邮箱）Three recommendation letters (to be sent directly by the recommender to the contact’s email)

五、应聘方式

请应聘者将申请材料通过电子邮件发送至hemuxinya@cpu.edu.cn（何老师）。邮件标题请注明：“应聘博士后+姓名”字样。应聘材料将予以严格保密。经初步审核通过者，课题组将尽快安排面试。

How to apply

Interested applicants should send their application materials (except the recommendation letters) via email to hemuxinya@cpu.edu.cn (Dr. Hemu). Please indicate Postdoc Application + Your Name in the email subject line. All application materials will be treated with strict confidentiality. After an initial review, the research group will arrange interviews for qualified candidates as soon as possible.

来源：http://rsc.cpu.edu.cn/c5/89/c4809a181641/page.htm

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